Which is a contraindication for the administration of tissue plasminogen activator (t-pa)?9/25/2023 Avoid intramuscular injections and other trauma as bleeding from recent puncture sites or other recent trauma may occur. In a trial of 2,965 patients administered RETAVASE, the overall rate of in-hospital, intracranial hemorrhage was 0.8%. RETAVASE can cause significant and sometimes fatal bleeding. Intracranial neoplasm, arteriovenous malformation, or aneurysm.Recent intracranial or intraspinal surgery or serious head trauma.RETAVASE ® (reteplase) for injection is contraindicated in patients with:
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